Researchers assessment the transmission, origin, pathogenesis, animal mannequin, and prognosis of the Zika virus


Announcement of a new article publication for Zoonoses magazine. Dallas Vue and Qiyi Tang from Howard University College of Medicine, Washington, DC, USA, review the transmission, origin, pathogenesis, animal model, and diagnosis of Zika virus.

The Zika virus (ZIKV) was first discovered in Uganda in 1947. ZIKV didn’t get any notable attention until Brazil hosted the 2016 Summer Olympics and ZIKV reached global audiences. ZIKV is a flavivirus that is transmitted primarily through mosquito bites, sexual intercourse, and to a lesser extent, breastfeeding.

The recent discovery of how ZIKV causes congenital neurodevelopmental defects, including microcephaly, has led to a reassessment of the importance of ZIKV’s interaction with centrosome organization, as centrosomes play an important role in cell division. When ZIKV disrupts centrosome organization and mitotic abnormalities, the differentiation of neural progenitor cells is altered, resulting in cell cycle arrest, increased apoptosis, and inhibition of neural progenitor cell differentiation; later, abnormalities in neural cell development can lead to microcephaly.

To help understand the importance of ZIKV infection, the authors of this article provide an overview of its history, routes of transmission, pathogenesis, animal models, and diagnosis.


Journal reference:

Vue, D & Tang, Q., (2021) Overview of the Zika Virus: Transmission, Origin, Pathogenesis, Animal Model, and Diagnosis. Molecular nutrition and food research.

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